2-Bromoethanol → (R)-1-Methyl-1,2,3,4-tetrahydroisoquinoline

HRID 1604030노트

반응식

HRID 1604030 반응식
[CH3:1][C@@H:2]([NH2:9])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.Br[CH2:11][CH2:12]O>ClCCl>[CH3:1][C@@H:2]1[C:3]2[C:8](=[CH:7][CH:6]=[CH:5][CH:4]=2)[CH2:12][CH2:11][NH:9]1

참가 물질

4

반응물 2

HCID 108982-BromoethanolHCID 6431891-Phenethylamine, (+)-

생성물 1

HCID 11084033(R)-1-Methyl-1,2,3,4-tetrahydroisoquinoline수율 85,303.602%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

반응 조건

온도
51 °C

실험 절차

51.45 g(0.43 mmole) of (R)-(+)-α-methylbenzylamine was dissolved in 52 ml of dichloromethane and 63.78 g(0.51 mmole) of 2-bromoethanol was added thereto. This mixture was stirred at 51° C. for 50 hours to complete the reaction. The reaction solution was concentrated under reduced pressure and the residue was subjected to fractional distillation to obtain 54 g of the title compound having pale yellow color.

후처리

  1. customthe reaction
  2. concentrationThe reaction solution was concentrated under reduced pressure
  3. distillationthe residue was subjected to fractional distillation

출처 및 근거

ORD 기록
ord-df70338bc03e4c9dbabd52dcb029ba68
출처 데이터셋
uspto-grants-1999_11
특허 번호
US05990311

반응 노트

불러오는 중…