Water → HCID 15435727, 화합물

HRID 1604480노트

반응식

HRID 1604480 반응식
[C:1]([NH:4][CH:5]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[CH2:7][CH2:6]1)(=[O:3])[CH3:2].O.[N+:15](C)([O-:17])=[O:16]>>[C:1]([NH:4][CH:5]1[C:13]2[C:8](=[CH:9][CH:10]=[C:11]([N+:15]([O-:17])=[O:16])[CH:12]=2)[CH2:7][CH2:6]1)(=[O:3])[CH3:2]

참가 물질

4

반응물 3

HCID 962Water2회HCID 6375NitromethaneHCID 302326N-(2,3-dihydro-1H-inden-1-yl)acetamide

생성물 1

HCID 15435727HCID 15435727, 화합물

실험 절차

To an ice-cooled suspension of (rac)-N-acetyl-1-aminoindan (Ex. 17, 17.5 g, 0.1 mole) in nitromethane (165 ml), was added dropwise a nitrating mixture (H2SO4HNO3, H2O ) while the temperature was kept between 8° C. and 2° C. stirring was continued for 1.5 hours in the ice-bath and the mixture was then poured on to a mechanically stirred mixture of ice (500 g) and water (1300 ml) stirring being continued for 1 hour. The suspension was filtered, the white solid washed with water and dried (14.05 g, 63.9%). It is sufficiently pure for hydrogenation (Ex. 59).

후처리

  1. customwas kept between 8° C. and 2° C.
  2. stirringstirring
  3. filtrationThe suspension was filtered
  4. washthe white solid washed with water
  5. customdried (14.05 g, 63.9%)

출처 및 근거

ORD 기록
ord-30addad3bf1e4f1c9de0e98211d8ed68
출처 데이터셋
uspto-grants-1999_11
특허 번호
US05994408

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