Triethylamine → 2,6-Dichloro-1-methylsulfonyloxymethyl-3-(methoxymethoxy)benzene

HRID 1604536노트

반응식

HRID 1604536 반응식
[Cl:1][C:2]1[C:9]([O:10][CH2:11][O:12][CH3:13])=[CH:8][CH:7]=[C:6]([Cl:14])[C:3]=1[CH2:4][OH:5].C(N(CC)CC)C.[CH3:22][S:23](Cl)(=[O:25])=[O:24]>ClCCl>[Cl:14][C:6]1[CH:7]=[CH:8][C:9]([O:10][CH2:11][O:12][CH3:13])=[C:2]([Cl:1])[C:3]=1[CH2:4][O:5][S:23]([CH3:22])(=[O:25])=[O:24]

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 536407392,6-Dichloro-3-(methoxymethoxy)benzyl alcohol

생성물 1

HCID 196032302,6-Dichloro-1-methylsulfonyloxymethyl-3-(methoxymethoxy)benzene

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

To a solution of 2,6-dichloro-3-(methoxymethoxy)benzyl alcohol (1.1 g) and triethylamine (563 mg) in dichloromethane was added a solution of methanesulfonyl chloride (585 mg) in dichloromethane at <20° C. over 5 minutes under nitrogen atmosphere, and the mixture was stirred at the same temperature for 30 minutes and under ice-cooling for 30 minutes. The reaction mixture was washed with saturated sodium bicarbonate solution and brine, dried over magnesium sulfate and evaporated in vacuo to give 1,3-dichloro-2-methanesulfonyloxymethyl-4-(methoxymethoxy)benzene.

후처리

  1. temperaturecooling for 30 minutes
  2. washThe reaction mixture was washed with saturated sodium bicarbonate solution and brine
  3. dry with materialdried over magnesium sulfate
  4. customevaporated in vacuo

출처 및 근거

ORD 기록
ord-136e26488a2d4c9cbb0a13c1f20ad7fb
출처 데이터셋
uspto-grants-1999_11
특허 번호
US05994368

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