Potassium Carbonate → Methyl 6-hydroxymethyl-3-methylquinoline-2-carboxylate

HRID 1604548노트

반응식

HRID 1604548 반응식
C([O:4][CH2:5][C:6]1[CH:7]=[C:8]2[C:13](=[CH:14][CH:15]=1)[N:12]=[C:11]([C:16]([O:18][CH2:19]C)=[O:17])[C:10]([CH3:21])=[CH:9]2)(=O)C.C(=O)([O-])[O-].[K+].[K+]>CO>[OH:4][CH2:5][C:6]1[CH:7]=[C:8]2[C:13](=[CH:14][CH:15]=1)[N:12]=[C:11]([C:16]([O:18][CH3:19])=[O:17])[C:10]([CH3:21])=[CH:9]2

참가 물질

4

반응물 2

HCID 11430Potassium CarbonateHCID 19603481Ethyl 6-acetoxymethyl-3-methylquinoline-2-carboxylate

생성물 1

HCID 19603207Methyl 6-hydroxymethyl-3-methylquinoline-2-carboxylate수율 5.9%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A mixture of ethyl 6-acetoxymethyl-3-methylquinoline-2-carboxylate (420 mg) and potassium carbonate in methanol was stirred for 30 minutes under ice-cooling. After filtration the filtrate was concentrated and partitioned between ethyl acetate and water. The organic layer was washed with water, dried over magnesium sulfate and concentrated to give methyl 6-hydroxymethyl-3-methylquinoline-2-carboxylate (20 mg).

후처리

  1. temperaturecooling
  2. filtrationAfter filtration the filtrate
  3. concentrationwas concentrated
  4. custompartitioned between ethyl acetate and water
  5. washThe organic layer was washed with water
  6. dry with materialdried over magnesium sulfate
  7. concentrationconcentrated

출처 및 근거

ORD 기록
ord-88db145c2b284e7a8be0441b53a3e69c
출처 데이터셋
uspto-grants-1999_11
특허 번호
US05994368

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