Dichloromethane → Methyl 6-formyl-3-methylquinoline-2-carboxylate

HRID 1604549노트

반응식

HRID 1604549 반응식
[OH:1][CH2:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[N:9]=[C:8]([C:13]([O:15][CH3:16])=[O:14])[C:7]([CH3:17])=[CH:6]2.C(N(CC)CC)C.ClCCl>O>[CH:2]([C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[N:9]=[C:8]([C:13]([O:15][CH3:16])=[O:14])[C:7]([CH3:17])=[CH:6]2)=[O:1]

참가 물질

5

반응물 3

HCID 6344DichloromethaneHCID 8471TriethylamineHCID 19603207Methyl 6-hydroxymethyl-3-methylquinoline-2-carboxylate

생성물 1

HCID 19603457Methyl 6-formyl-3-methylquinoline-2-carboxylate수율 77.9%

시약·촉매·용매 1

HCID 962Water용매2회

실험 절차

To a mixture of methyl 6-hydroxymethyl-3-methylquinoline-2-carboxylate (193 mg), triethylamine (422 mg) dimethyl sulfoxide (2 ml) and dichloromethane (2 ml) was added portionwise sulfur trioxide pyridine complex (266 mg) in water bath and the mixture was stirred for 2 hours at the same temperature. The reaction mixture was poured into water and extracted with ethyl acetate. The organic layer was washed with water and brine, dried over magnesium sulfate and evaporated in vacuo. The residue was purified by preparative thin-layer chromatography (n-hexane:ethyl acetate=1:1, V/V) to give methyl 6-formyl-3-methylquinoline-2-carboxylate (149 mg).

후처리

  1. extractionextracted with ethyl acetate
  2. washThe organic layer was washed with water and brine
  3. dry with materialdried over magnesium sulfate
  4. customevaporated in vacuo
  5. customThe residue was purified by preparative thin-layer chromatography (n-hexane:ethyl acetate=1:1, V/V)

출처 및 근거

ORD 기록
ord-8bdceb1ac4fb422f921b3ce7c2e156b6
출처 데이터셋
uspto-grants-1999_11
특허 번호
US05994368

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