Sulfuric Acid → HCID 19603840, 화합물

HRID 1604628노트

반응식

HRID 1604628 반응식
[CH2:1]([O:8][C:9]1[CH:10]=[CH:11][C:12]([N+:19]([O-:21])=[O:20])=[C:13]([CH2:15][C:16]([OH:18])=[O:17])[CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.S(=O)(=O)(O)O.[CH:27](O)([CH3:29])[CH3:28]>>[CH2:1]([O:8][C:9]1[CH:10]=[CH:11][C:12]([N+:19]([O-:21])=[O:20])=[C:13]([CH2:15][C:16]([O:18][CH:27]([CH3:29])[CH3:28])=[O:17])[CH:14]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

4

반응물 3

HCID 1118Sulfuric AcidHCID 3776IsopropanolHCID 19603791HCID 19603791, 화합물

생성물 1

HCID 19603840HCID 19603840, 화합물

실험 절차

A mixture of 5-benzyloxy-2-nitrophenylacetic acid (4.0 g) and conc. sulphuric acid (0.6 ml) in isopropyl alcohol (40 ml) was stirred under reflux for 1 day. After removal of solvent by evaporation, the resulting residue was dissolved with ethyl acetate. The ethyl acetate extract was washed successively with aqueous sodium hydrogen carbonate solution, water, and brine, and was dried over magnesium sulfate, and concentrated under reduced pressure to give isopropyl 5-benzyloxy-2-nitrophenylacetate (4.20 g).

후처리

  1. temperatureunder reflux for 1 day
  2. customAfter removal of solvent
  3. customby evaporation
  4. dissolutionthe resulting residue was dissolved with ethyl acetate
  5. extractionThe ethyl acetate extract
  6. washwas washed successively with aqueous sodium hydrogen carbonate solution, water, and brine
  7. dry with materialwas dried over magnesium sulfate
  8. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-caa0200444f44ff19a4f554d46e8c6f1
출처 데이터셋
uspto-grants-1999_11
특허 번호
US05994378

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