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Water → 3-[2-(4-Tert-butylthiazol-2-yl)benzofuran-5-yl]propanol

HRID 1604636
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HRID 1604636 반응식
[H-].[Al+3].[Li+].[H-].[H-].[H-].[C:7]([C:11]1[N:12]=[C:13]([C:16]2[O:17][C:18]3[CH:24]=[CH:23][C:22]([CH2:25][CH2:26][C:27](OCC)=[O:28])=[CH:21][C:19]=3[CH:20]=2)[S:14][CH:15]=1)([CH3:10])([CH3:9])[CH3:8].O>O1CCCC1>[C:7]([C:11]1[N:12]=[C:13]([C:16]2[O:17][C:18]3[CH:24]=[CH:23][C:22]([CH2:25][CH2:26][CH2:27][OH:28])=[CH:21][C:19]=3[CH:20]=2)[S:14][CH:15]=1)([CH3:10])([CH3:8])[CH3:9]
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참가 물질

5

반응물 3

HCID 962WaterHCID 19603662Ethyl 3-[2-(4-tert-butylthiazol-2-yl)benzofuran-5-yl]propionateHCID 21226445Aluminium lithium hydride

생성물 1

HCID 196037673-[2-(4-Tert-butylthiazol-2-yl)benzofuran-5-yl]propanol수율 73.2%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

Lithium aluminium hydride (0.14 g) was added to a solution of ethyl 3-[2-(4-tert-butylthiazol-2-yl)benzofuran-5-yl]propionate (0.65 g) in tetrahydrofuran (10 ml) at room temperature under an inert atmosphere. After the mixture was stirred for 2 hours, water was added to the mixture. The resulting precipitates were filtered off and the filtrate was extracted with ethyl acetate. The organic layer was washed with brine, dried over magnesium sulfate and concentrated under reduced pressure to give 3-[2-(4-tert-butylthiazol-2-yl)benzofuran-5-yl]propanol (0.42 g).

후처리

  1. customThe resulting precipitates
  2. filtrationwere filtered off
  3. extractionthe filtrate was extracted with ethyl acetate
  4. washThe organic layer was washed with brine
  5. dry with materialdried over magnesium sulfate
  6. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-f0d9653e011b491d9e2f28933dd81c28
출처 데이터셋
uspto-grants-1999_11
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US05994378

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