참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | Propanoic acid, 2-bromo-2-methyl-, ethyl ester | HCID 11745 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | Ethyl 2-[4-(2,2-dichlorocyclopropyl)phenoxy]-2-methylpropionate | HCID 103600 | — |
| 반응물 | 2-(4-Acetylphenoxy)-2-methylpropionic acid | HCID 104106 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | Ciprofibrate | HCID 2763 | — |
| 생성물 | Ciprofibrate Impurity D | HCID 9944254 | — |
반응 단계
Alternatively, methyl 2-[p-(2,2-dichlorocyclopropyl)phenoxy]-2-methylpropionate was prepared from 20 g. of p-(2,2-dichlorocyclopropyl)phenol [Example 24, part (a)], 38 g. of ethyl 2-bromo-2-methylpropionate and 42 g. of potassium carbonate in 100 ml. of acetonitrile. The ethyl 2-bromo-2-methylpropionate was added in two equal portions, the second portion being added after seven hours of heating at reflux. The reaction mixture was heated at reflux for about three days and the product isolated to give 32 g. of ethyl 2-[p-(2,2-dichlorocyclopropyl)phenoxy]-2-methylpropionate. The latter was hydrolyzed in the usual manner with ethanolic sodium hydroxide to produce 2-[p-(2,2-dichlorocyclopropyl)phenoxy]-2-methylpropionic acid, identical with the compound formed in Example 24, part (b).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US03948973 |
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| 출처 데이터셋 | uspto-grants-1976_04 |
|---|
| ORD ID | ord-2c9e5d49e228447185367f2eb6f4eab1 |
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| 출처 메모 | uspto-grants-1976_04 |
|---|
