Methane → HCID 12650295, 화합물

HRID 1605168노트

반응식

HRID 1605168 반응식
Cl[C:2]1[CH:10]=[C:9]([Cl:11])[CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[CH3:12][C:13]1[CH:18]=[CH:17][C:16]([OH:19])=[CH:15][CH:14]=1.C(=O)([O-])[O-].[K+].[K+].C>O.[Cu].CN(C)C=O>[CH3:12][C:13]1[CH:18]=[CH:17][C:16]([O:19][C:2]2[CH:10]=[C:9]([Cl:11])[CH:8]=[CH:7][C:3]=2[C:4]([OH:6])=[O:5])=[CH:15][CH:14]=1

참가 물질

8

반응물 4

HCID 297MethaneHCID 2879P-CresolHCID 57872,4-Dichlorobenzoic AcidHCID 11430Potassium Carbonate

생성물 1

HCID 12650295HCID 12650295, 화합물

시약·촉매·용매 3

HCID 23978Copper촉매HCID 962Water용매HCID 6228Dimethylformamide용매

실험 절차

A mixture of 15 g. of 2,4-dichlorobenzoic acid, 10 g. of p-methylphenol, 0.5 g. of copper powder and 20 g. of anhydrous potassium carbonate in 200 ml. of dimethylformamide is heated to 165° C and maintained thereat with stirring and under a nitrogen atmosphere. After monitoring via tlc indicates the reaction is substantially complete, the reaction mixture is diluted with water, treated with charcoal, filtered and the clear filtrate acidified. The precipitate is isolated by suction filtration, washed neutral and dried to give 2-(p-methylphenyloxy)-4-chlorobenzoic acid.

후처리

  1. additionA mixture of 15 g
  2. temperaturemaintained
  3. filtrationfiltered
  4. customThe precipitate is isolated by suction filtration
  5. washwashed neutral
  6. customdried

출처 및 근거

ORD 기록
ord-ea08849779bf48ec85d709fd9f0fa43b
출처 데이터셋
uspto-grants-1976_04
특허 번호
US03949084

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