3-Methoxyphenol → 1,3-Dimethyl-4-(m-methoxyphenyloxy)-benzene

HRID 1605170

반응식

HRID 1605170 반응식
[CH3:1][C:2]1[CH:7]=[CH:6][C:5](Br)=[C:4]([CH3:9])[CH:3]=1.[CH3:10][O:11][C:12]1[CH:13]=[C:14]([OH:18])[CH:15]=[CH:16][CH:17]=1.CN(C)C(=O)N(C)C.CN1CCCC1=O>O>[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([O:18][C:14]2[CH:15]=[CH:16][CH:17]=[C:12]([O:11][CH3:10])[CH:13]=2)=[C:4]([CH3:9])[CH:3]=1

참가 물질

6

반응물 4

HCID 90073-MethoxyphenolHCID 12437TetramethylureaHCID 13387N-methyl-2-pyrrolidoneHCID 68503Benzene, 1-bromo-2,4-dimethyl-

생성물 1

HCID 215496571,3-Dimethyl-4-(m-methoxyphenyloxy)-benzene

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A mixture of 1,3-dimethyl-4-bromobenzene, 10.5 g. of m-methoxyphenol, 4.65 g. of cuprous oxide, 40 ml. of tetramethylurea, and 75 ml. of N-methylpyrrolidone is stirred at 165° for 96 hours. The resultant mixture is diluted with water and extracted with methylene chloride. The methylene chloride extracts are chromatographed on 300 g. of alumina with gradient elution using hexane:ether to give 1,3-dimethyl-4-(m-methoxyphenyloxy)-benzene.

후처리

  1. extractionextracted with methylene chloride
  2. customThe methylene chloride extracts are chromatographed on 300 g
  3. washof alumina with gradient elution

출처 및 근거

ORD 기록
ord-6b639ce2671f4045b8a7ddbf95e838ee
출처 데이터셋
uspto-grants-1976_04
특허 번호
US03949084

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