Dichloromethane → HCID 68137584, 화합물

HRID 1605189노트

반응식

HRID 1605189 반응식
[CH3:1][C:2]1([O:8][C:9]([NH:11][C@H:12]([C:20]([OH:22])=[O:21])[CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=[O:10])[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3]1.Cl.[CH3:24][O:25][C:26](=[O:30])[C@H:27]([CH3:29])[NH2:28].C(Cl)Cl>C(N(CC)CC)C>[CH3:1][C:2]1([O:8][C:9]([NH:11][C@H:12]([C:20]([OH:22])=[O:21])[CH2:13][C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=2)=[O:10])[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7]1.[CH3:24][O:25][C:26](=[O:30])[C@H:27]([CH3:29])[NH2:28]

참가 물질

5

반응물 3

HCID 6344DichloromethaneHCID 2733257Alanine methyl ester hydrochlorideHCID 54520100HCID 54520100, 화합물

생성물 1

HCID 68137584HCID 68137584, 화합물

시약·촉매·용매 1

HCID 8471Triethylamine용매

실험 절차

A solution of 0.67 mM of the hydroxysuccinimide ester of N-(1-methylcyclohexyloxycarbonyl) phenylalanine and 0.70 mM of alanine methyl ester hydrochloride in 10 ml. of methylene chloride is treated with triethylamine until the pH is adjusted to 7.6-8.0. Reaction is stirred six hours and the reaction mixture is washed according to the following procedure: one time with dilute sodium bicarbonate solution; once with 50% saturated sodium chloride solution; once with 0.2 N sulfuric acid saturated with sodium sulfate; and two times with 50% saturated sodium chloride solution. The resulting material is dried over sodium sulfate and the washing procedure repeated. The solvent is removed in vacuo to afford N-(1-methylcyclohexyloxycarbonyl) phenylalanine-alanine methyl ester.

후처리

  1. customReaction
  2. washthe reaction mixture is washed
  3. dry with materialThe resulting material is dried over sodium sulfate
  4. customThe solvent is removed in vacuo

출처 및 근거

ORD 기록
ord-cdb3420a54b247efaf2fc0f4e2d209a3
출처 데이터셋
uspto-grants-1976_04
특허 번호
US03948971

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