3-Nitro-4-phenyl-5-sulfamylbenzoic acid → 3-Amino-4-phenyl-5-sulfamylbenzoic acid

HRID 1605575노트

반응식

HRID 1605575 반응식
[N+:1]([C:4]1[CH:5]=[C:6]([CH:10]=[C:11]([S:19](=[O:22])(=[O:21])[NH2:20])[C:12]=1[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[C:7]([OH:9])=[O:8])([O-])=O>C(O)(=O)C.[Pd]>[NH2:1][C:4]1[CH:5]=[C:6]([CH:10]=[C:11]([S:19](=[O:22])(=[O:21])[NH2:20])[C:12]=1[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[C:7]([OH:9])=[O:8]

참가 물질

4

반응물 1

HCID 215468433-Nitro-4-phenyl-5-sulfamylbenzoic acid

생성물 1

HCID 215468413-Amino-4-phenyl-5-sulfamylbenzoic acid

시약·촉매·용매 2

HCID 176Acetic Acid용매HCID 23938Palladium용매

실험 절차

To a solution of 3-nitro-4-phenyl-5-sulfamylbenzoic acid (8.5 g) in acetic acid (100 ml), palladium (10%) on carbon (1.5 g) is added, and the mixture is hydrogenated. After 2-2.5 hours the theoretical amount of hydrogen has been absorbed, and the hydrogen uptake has subsided. The catalyst is removed by filtration, and the filtrate is evaporated in vacuo. The residue is recrystallized from acetic acid to give 3-amino-4-phenyl-5-sulfamylbenzoic acid with a melting point of 232.5°-237° C.

후처리

  1. customAfter 2-2.5 hours the theoretical amount of hydrogen has been absorbed
  2. customThe catalyst is removed by filtration
  3. customthe filtrate is evaporated in vacuo
  4. customThe residue is recrystallized from acetic acid

출처 및 근거

ORD 기록
ord-8cf6a0da7ddb42d4960d7d943f93761f
출처 데이터셋
uspto-grants-1976_04
특허 번호
US03950380

반응 노트

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