p-Toluenesulfonic acid → HCID 20367301, 화합물

HRID 1605719노트

반응식

HRID 1605719 반응식
[I:1][C:2]1[CH:10]=[CH:9][C:5]([CH2:6][NH:7][NH2:8])=[CH:4][CH:3]=1.C([O:13][C:14](=O)[CH:15]=[C:16]([NH2:20])OCC)C.C1(C)C=CC(S(O)(=O)=O)=CC=1>C(O)C>[NH2:20][C:16]1[NH:8][N:7]([CH2:6][C:5]2[CH:9]=[CH:10][C:2]([I:1])=[CH:3][CH:4]=2)[C:14](=[O:13])[CH:15]=1

참가 물질

5

반응물 3

HCID 6101p-Toluenesulfonic acidHCID 278451beta-Aminobeta-ethoxyacrylic acid ethyl esterHCID 20367299[(4-Iodophenyl)methyl]hydrazine

생성물 1

HCID 20367301HCID 20367301, 화합물

시약·촉매·용매 1

HCID 702Ethanol용매2회

실험 절차

A solution of 25.5 g of p-iodobenzylhydrazine in 100 ml of ethanol was added dropwise, under nitrogen, to a solution of 16.2 g of β-amino-β-ethoxyacrylic acid ethyl ester and 1 g of p-toluenesulphonic acid in 250 ml of ethanol. After stirring overnight, the solvent was distilled off in vacuo and the compound identified above was obtained as a residue and recrystallised from ethanol. Melting point: 158°, 15 g (47%).

후처리

  1. distillationthe solvent was distilled off in vacuo
  2. customabove was obtained as a residue
  3. customrecrystallised from ethanol

출처 및 근거

ORD 기록
ord-2a3feffae3c7497ebfe20f884684f849
출처 데이터셋
uspto-grants-1976_04
특허 번호
US03950528

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