p-Toluenesulfonic acid → 3-Amino-1-(2-fluorobenzyl)-pyrazol-5-one
반응식
C([O:3][C:4](=O)[CH:5]=[C:6]([NH2:10])OCC)C.C1(C)C=CC(S(O)(=O)=O)=CC=1.[F:23][C:24]1[CH:32]=[CH:31][CH:30]=[CH:29][C:25]=1[CH2:26][NH:27][NH2:28]>C(O)C>[NH2:10][C:6]1[NH:28][N:27]([CH2:26][C:25]2[CH:29]=[CH:30][CH:31]=[CH:32][C:24]=2[F:23])[C:4](=[O:3])[CH:5]=1참가 물질
5
실험 절차
30.2 g of β-amino-β-ethoxyacrylic acid ethyl ester together with 2 g of p-toluenesulphonic acid were dissolved in 300 ml of ethanol and 27.1 g of o-fluorobenzylhydrazine were added under nitrogen. After stirring for 2 hours, the mixture was left to stand overnight and the compound identified above, which had separated out as a precipitate, was filtered off and recrystallised from ethanol. Melting point: 146°, 11 g (27%).
후처리
- waitthe mixture was left
- waitto stand overnight
- customhad separated out as a precipitate
- filtrationwas filtered off
- customrecrystallised from ethanol
출처 및 근거
- ORD 기록
- ord-dc04bdb333de40a0b0bed98c1f8a5dd5
- 출처 데이터셋
- uspto-grants-1976_04
- 특허 번호
- US03950528
반응 노트
불러오는 중…