Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Pyridine → 1-(tert-Butoxycarbonyl)-4-((p-toluenesulfonyloxy)methyl)piperidine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Pyridine | HCID 1049 | — |
| 반응물 | o-Toluenesulfonyl chloride | HCID 8623 | — |
| 반응물 | Tert-butyl 4-(hydroxymethyl)piperidine-1-carboxylate | HCID 2764081 | — |
| 용매 | Chloroform | HCID 6212 | — |
| 생성물 | 1-(tert-Butoxycarbonyl)-4-((p-toluenesulfonyloxy)methyl)piperidine | HCID 10642851 | — |
반응 단계
A solution of N-Boc-4-piperidinemethanol, 5.0 g (23.2 mmol) in chloroform, 50 mL, was prepared. Toluene sulfonyl chloride, 5.75 g (30.2 mmol), in 5.6 mL of pyridine (69.6 mmol) was added. The solution was stirred under nitrogen allowed to stir for 24 hours. Standard workup and chromatographic purification provided the title compound. Yield 6.0 g
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07737127B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-c7699937794840df9e4605140d7e4fc6 |
| 출처 메모 | uspto-grants-2010_06 |