Triethylamine → HCID 21545008, 화합물

HRID 1605804노트

반응식

HRID 1605804 반응식
[CH3:1][S:2]([C:5]1[S:6][C:7]([N:10]([CH3:14])[C:11](Cl)=[O:12])=[N:8][N:9]=1)(=[O:4])=[O:3].[O:15]1[CH2:20][CH2:19][CH2:18][O:17][CH:16]1[CH2:21][NH2:22].C(N(CC)CC)C>C1C=CC=CC=1>[CH3:1][S:2]([C:5]1[S:6][C:7]([N:10]([CH3:14])[C:11]([NH:22][CH2:21][CH:16]2[O:17][CH2:18][CH2:19][CH2:20][O:15]2)=[O:12])=[N:8][N:9]=1)(=[O:4])=[O:3]

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 212488031-(1,3-Dioxan-2-yl)methanamineHCID 21544998HCID 21544998, 화합물

생성물 1

HCID 21545008HCID 21545008, 화합물

시약·촉매·용매 1

HCID 241Benzene용매

실험 절차

N-(2-Methylsulfonyl-1,3,4-thiadiazol-5-yl)-N-methylcarbamoyl chloride (0.05 mole), N-(1,3-dioxan-2-ylmethyl)amine (0.05 mole), triethylamine (0.07 mole) and benzene (200 ml) are charged into a glass reaction vessel equipped with a mechanical stirrer, thermometer and reflux condenser. The reaction mixture is then heated at reflux for a period of about 4 hours. After this time the mixture is cooled to room temperature and is filtered. The filtrate is washed with water and is dried over anhydrous magnesium sulfate. The dried solution is then stripped of solvent under reduced pressure to yield the desired product N-(2-methylsulfonyl-1,3,4-thiadiazol-5-yl)-N-methyl-N'-(1,3-dioxan-2-ylmethyl)urea.

후처리

  1. customequipped with a mechanical stirrer
  2. temperaturethermometer and reflux condenser
  3. temperatureThe reaction mixture is then heated
  4. temperatureat reflux for a period of about 4 hours
  5. filtrationis filtered
  6. washThe filtrate is washed with water
  7. dry with materialis dried over anhydrous magnesium sulfate

출처 및 근거

ORD 기록
ord-5f72656f54184a46a7fe6c815f28720d
출처 데이터셋
uspto-grants-1976_04
특허 번호
US03951640

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