Dimethylformamide → N-Carbobenzyloxymethylimidazoline

HRID 1605851

반응식

HRID 1605851 반응식
[NH:1]1[CH2:5][CH2:4][N:3]=[CH:2]1.CN(C)C=O.Br[CH2:12][C:13]([O:15][CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)=[O:14]>O>[C:13]([CH2:12][N:3]1[CH2:4][CH2:5][N:1]=[CH:2]1)([O:15][CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)=[O:14]

참가 물질

5

반응물 3

HCID 6228DimethylformamideHCID 62576Benzyl bromoacetateHCID 681562-Imidazoline

생성물 1

HCID 20369282N-Carbobenzyloxymethylimidazoline

시약·촉매·용매 1

HCID 962Water용매

실험 절차

To a solution of 14.0 g. (0.2 mole) of imidazoline in 150 ml. of dry dimethylformamide is added dropwise with cooling 22.9 g. (0.1 mole) of benzyl bromoacetate. When the addition is complete, the reaction is warmed to 50°-60° C. for several hours, and is then cooled and diluted with water (250 ml.). The product is extracted with diethyl ether, and the extracts are combined and washed several times with a saturated brine solution. The ether phase is dried over sodium sulfate and concentrated to an oil, which is used in the next reaction without purification.

후처리

  1. temperaturewith cooling 22.9 g
  2. additionWhen the addition
  3. temperaturethe reaction is warmed to 50°-60° C. for several hours
  4. temperatureis then cooled
  5. extractionThe product is extracted with diethyl ether
  6. washwashed several times with a saturated brine solution
  7. dry with materialThe ether phase is dried over sodium sulfate
  8. concentrationconcentrated to an oil, which
  9. customis used in the next reaction without purification

출처 및 근거

ORD 기록
ord-0c00c646f09e4937a3ba3990e96e7f8a
출처 데이터셋
uspto-grants-1976_04
특허 번호
US03951952

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