2,6-Dimethylaniline → N-(2',6'-dimethylphenyl)-1-methoxymethylethylamine

HRID 1606267노트

반응식

HRID 1606267 반응식
[NH2:1][C:2]1[C:3]([CH3:9])=[CH:4][CH:5]=[CH:6][C:7]=1[CH3:8].[CH3:10][O:11][CH2:12][CH:13](OS(C1C=CC(C)=CC=1)(=O)=O)[CH3:14]>C1(C)C=CC=CC=1.CCOCC>[CH3:10][O:11][CH2:12][CH:13]([NH:1][C:2]1[C:7]([CH3:8])=[CH:6][CH:5]=[CH:4][C:3]=1[CH3:9])[CH3:14]

참가 물질

5

반응물 2

HCID 68962,6-DimethylanilineHCID 1270077423946-74-9

생성물 1

HCID 10899497N-(2',6'-dimethylphenyl)-1-methoxymethylethylamine

시약·촉매·용매 2

HCID 1140Toluene용매HCID 3283Diethyl Ether용매

실험 절차

A solution of 484 g (4 mole) of 2,6-xylidine and 490 g (2 mole) of p-toluenesulphonic acid-(1-methoxyprop-2-yl)-ester in 1000 ml of toluene is refluxed for 25 hours. The reaction mixture is cooled, then made alkaline and diluted with ether. The organic phase is repeatedly washed with water and dried with magnesium sulphate. Evaporation of the solvent and subsequent distillation of the residue yields the desired N-(1-methoxyprop-2-yl)-2,6-xylidine with a boiling point of 70°-72°C/0.4 Torr.

후처리

  1. temperatureThe reaction mixture is cooled
  2. washThe organic phase is repeatedly washed with water
  3. dry with materialdried with magnesium sulphate
  4. customEvaporation of the solvent and subsequent distillation of the residue

출처 및 근거

ORD 기록
ord-5d435b69e1b04433ae4ed8e4a39b7333
출처 데이터셋
uspto-grants-1976_04
특허 번호
US03952056

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