Thionyl Chloride → Methyl 1-chloroindan-4-carboxylate

HRID 1606721

반응식

HRID 1606721 반응식
O[CH:2]1[C:10]2[CH:9]=[CH:8][CH:7]=[C:6]([C:11]([O:13][CH3:14])=[O:12])[C:5]=2[CH2:4][CH2:3]1.S(Cl)([Cl:17])=O>>[Cl:17][CH:2]1[C:10]2[CH:9]=[CH:8][CH:7]=[C:6]([C:11]([O:13][CH3:14])=[O:12])[C:5]=2[CH2:4][CH2:3]1

참가 물질

3

반응물 2

HCID 24386Thionyl ChlorideHCID 20310103Methyl 1-hydroxyindan-4-carboxylate

생성물 1

HCID 20310089Methyl 1-chloroindan-4-carboxylate

실험 절차

In 6 ml. of chllroform is dissolved 5.7 g. of methyl 1-hydroxyindan-4-carboxylate and, under cooling with ice, the solution is stirred. Then, 3 ml. of thionyl chloride is added dropwise and, after the dropwise addition has been completed, the mixture is further stirred under cooling with ice for one hour. Then, the solvent and the excess thionyl chloride are distilled off under reduced pressure. The residue obtained is purified by column chromatography on silica gel (500 g. silica gel; eluant: chloroform). The procedure gives methyl 1-chloroindan-4-carboxylate as an oily product.

후처리

  1. dissolutionof chllroform is dissolved 5.7 g
  2. additionafter the dropwise addition
  3. stirringthe mixture is further stirred
  4. temperatureunder cooling with ice for one hour
  5. distillationThen, the solvent and the excess thionyl chloride are distilled off under reduced pressure
  6. customThe residue obtained
  7. customis purified by column chromatography on silica gel (500 g. silica gel; eluant: chloroform)

출처 및 근거

ORD 기록
ord-49d482482cf3431abc7d24e93cc534d1
출처 데이터셋
uspto-grants-1976_04
특허 번호
US03953500

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