HCID 131710167, 화합물 → H-Glu(OtBu)-Ser(tBu)-OtBu

HRID 1606828노트

반응식

HRID 1606828 반응식
[NH:1](C(OCC1C=CC=CC=1)=O)[C@H:2]([C:12]([NH:14][C@H:15]([C:22]([O:24][C:25]([CH3:28])([CH3:27])[CH3:26])=[O:23])[CH2:16][O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:13])[CH2:3][CH2:4][C:5](=[O:11])[O:6][C:7]([CH3:10])([CH3:9])[CH3:8]>[Pd]>[NH2:1][C@H:2]([C:12]([NH:14][C@H:15]([C:22]([O:24][C:25]([CH3:28])([CH3:27])[CH3:26])=[O:23])[CH2:16][O:17][C:18]([CH3:20])([CH3:19])[CH3:21])=[O:13])[CH2:3][CH2:4][C:5](=[O:11])[O:6][C:7]([CH3:8])([CH3:9])[CH3:10]

참가 물질

3

반응물 1

HCID 131710167HCID 131710167, 화합물

생성물 1

HCID 10916435H-Glu(OtBu)-Ser(tBu)-OtBu수율 83.4%

시약·촉매·용매 1

HCID 23938Palladium촉매

실험 절차

2.5 g. of palladium-on-carbon are added to the solution of 17.2 g. (32 mmoles) of Z-30-31-OtBu in 350 ml. of methanol, and gaseous hydrogen is bubbled into the mixture for 1 hour. The catalyst is removed by filtration, the filtrate is evaporated to dryness under reduced pressure, the solid residue is mixed with petroleum ether, and the mixture is filtered. 10.97 g. (83.4 %) of H-Glu(OtBu)-Ser(tBu)-OtBu are obtained. M.p.: 78°-82° C, Rf11 = 0.4.

후처리

  1. customof methanol, and gaseous hydrogen is bubbled into the mixture for 1 hour
  2. customThe catalyst is removed by filtration
  3. customthe filtrate is evaporated to dryness under reduced pressure
  4. additionthe solid residue is mixed with petroleum ether
  5. filtrationthe mixture is filtered

출처 및 근거

ORD 기록
ord-055ca1749ad24418b3d46b93683aecd7
출처 데이터셋
uspto-grants-1976_04
특허 번호
US03953415

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