O-((2E)-3-Chloro-2-propen-1-yl)hydroxylamine → HCID 178458082, 화합물

HRID 1606865노트

반응식

HRID 1606865 반응식
[CH3:1][N:2]1[CH:6]=[C:5]([CH:7]2[CH2:12][C:11](=[O:13])[CH:10]([C:14](=O)[CH2:15][CH3:16])[C:9](=[O:18])[CH2:8]2)[CH:4]=[N:3]1.[Cl:19]/[CH:20]=[CH:21]/[CH2:22][O:23][NH2:24]>>[Cl:19][CH:20]=[CH:21][CH2:22][O:23]/[N:24]=[C:14](/[CH:10]1[C:11](=[O:13])[CH2:12][CH:7]([C:5]2[CH:4]=[N:3][N:2]([CH3:1])[CH:6]=2)[CH2:8][C:9]1=[O:18])\[CH2:15][CH3:16]

참가 물질

3

반응물 2

HCID 158058O-((2E)-3-Chloro-2-propen-1-yl)hydroxylamineHCID 145764915-(1-methyl-1H-pyrazol-4-yl)-2-propionylcyclohexane-1,3-dione

생성물 1

HCID 178458082HCID 178458082, 화합물

실험 절차

To 200 ml of an ethanolic solution of 20.0 g (81 mmols) of 5-(1-methyl-1H-pyrazol-4-yl)-2-propionylcyclohexane-1,3-dione was added 210 ml (84 mmols) of 0.4 mol ethanolic solution of (E)-3-chloro-2-propenyloxyamine. The mixture was reacted for 8 hours with stirring. After completion of the reaction, the reaction mixture was concentrated under reduced pressure. The resulting crude product was purified by silica gel column chromatography (ethyl acetate) to give 12.5 g of the product.

후처리

  1. customThe mixture was reacted for 8 hours
  2. customAfter completion of the reaction
  3. concentrationthe reaction mixture was concentrated under reduced pressure
  4. customThe resulting crude product was purified by silica gel column chromatography (ethyl acetate)

출처 및 근거

ORD 기록
ord-bda6b4cfbc5f4d8b80bad58e57b74e72
출처 데이터셋
uspto-grants-1989_09
특허 번호
US04863504

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