O-((2E)-3-Chloro-2-propen-1-yl)hydroxylamine → 2-[(E)-N-(3-chloroprop-2-enoxy)-C-ethylcarbonimidoyl]-5-(2-methylpyrazol-3-yl)cyclohexane-1,3-dione

HRID 1606866노트

반응식

HRID 1606866 반응식
[CH3:1][N:2]1[C:6]([CH:7]2[CH2:12][C:11](=[O:13])[CH:10]([C:14](=O)[CH2:15][CH3:16])[C:9](=[O:18])[CH2:8]2)=[CH:5][CH:4]=[N:3]1.[Cl:19]/[CH:20]=[CH:21]/[CH2:22][O:23][NH2:24]>>[Cl:19][CH:20]=[CH:21][CH2:22][O:23]/[N:24]=[C:14](/[CH:10]1[C:11](=[O:13])[CH2:12][CH:7]([C:6]2[N:2]([CH3:1])[N:3]=[CH:4][CH:5]=2)[CH2:8][C:9]1=[O:18])\[CH2:15][CH3:16]

참가 물질

3

반응물 2

HCID 158058O-((2E)-3-Chloro-2-propen-1-yl)hydroxylamineHCID 145362755-(1-methyl-1H-pyrazol-5-yl)-2-propionylcyclohexane-1,3-dione

생성물 1

HCID 1415602412-[(E)-N-(3-chloroprop-2-enoxy)-C-ethylcarbonimidoyl]-5-(2-methylpyrazol-3-yl)cyclohexane-1,3-dione

실험 절차

To 5 ml of an ethanolic solution of 0.35 g (1.4 mmols) of 5-(1-methyl-1H-pyrazol-5-yl)-2-propionylcyclohexane-1,3-dione was added 3.8 ml (1.4 mmols) of 0.38 mol ethanolic solution of (E)-3-chloro-2-propenyloxyamine. The mixture was reacted for 10 hours with stirring. After completion of the reaction, the reaction mixture was concentrated under reduced pressure. The resulting crude product was purified by silica gel column chromatography (hexane:ethyl acetate=b 1:2) to give 0.25 g of the product.

후처리

  1. customThe mixture was reacted for 10 hours
  2. customAfter completion of the reaction
  3. concentrationthe reaction mixture was concentrated under reduced pressure
  4. customThe resulting crude product was purified by silica gel column chromatography (hexane:ethyl acetate=b 1:2)

출처 및 근거

ORD 기록
ord-5531e9712f6d42a1ab5f13ad87a3c89a
출처 데이터셋
uspto-grants-1989_09
특허 번호
US04863504

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