O-((2E)-3-Chloro-2-propen-1-yl)hydroxylamine → HCID 178458080, 화합물

HRID 1606868노트

반응식

HRID 1606868 반응식
[CH3:1][N:2]1[C:6]([CH:7]2[CH2:12][C:11](=[O:13])[CH:10]([C:14](=O)[CH2:15][CH3:16])[C:9](=[O:18])[CH2:8]2)=[CH:5][C:4]([CH3:19])=[N:3]1.[Cl:20]/[CH:21]=[CH:22]/[CH2:23][O:24][NH2:25]>CO>[Cl:20][CH:21]=[CH:22][CH2:23][O:24]/[N:25]=[C:14](/[CH:10]1[C:11](=[O:13])[CH2:12][CH:7]([C:6]2[N:2]([CH3:1])[N:3]=[C:4]([CH3:19])[CH:5]=2)[CH2:8][C:9]1=[O:18])\[CH2:15][CH3:16]

참가 물질

4

반응물 2

HCID 158058O-((2E)-3-Chloro-2-propen-1-yl)hydroxylamineHCID 145362605-(1,3-dimethyl-1H-pyrazol-5-yl)-2-propionylcyclohexane-1,3-dione

생성물 1

HCID 178458080HCID 178458080, 화합물

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To 10 ml of a solution of 5.60 g (21.3 mmols) of 5-(1,3-dimethyl-1H-pyrazol-5-yl)-2-propionylcyclohexane-1,3-dione in methanol was added 57 ml (21.7 mmols) of 0.38 mol ethanolic solution of (E)-3-chloro-2-propenyloxyamine. The mixture was reacted for 10 hours with stirring. After completion of the reaction, the reaction mixture was concentrated under reduced pressure. The resulting crude product was purified by silica gel column chromatography (hexane:ethyl acetate=2:1) to give 6.84 g of the product.

후처리

  1. customThe mixture was reacted for 10 hours
  2. customAfter completion of the reaction
  3. concentrationthe reaction mixture was concentrated under reduced pressure
  4. customThe resulting crude product was purified by silica gel column chromatography (hexane:ethyl acetate=2:1)

출처 및 근거

ORD 기록
ord-517fdeb7e1764c90831793729aa18792
출처 데이터셋
uspto-grants-1989_09
특허 번호
US04863504

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