Thionyl Chloride → 2-Bromomethylbenzoyl chloride

HRID 1606897

반응식

HRID 1606897 반응식
[Br:1][CH2:2][C:3]1[C:4]([C:9]([OH:11])=O)=[CH:5][CH:6]=[CH:7][CH:8]=1.S(Cl)([Cl:14])=O>C1C=CC=CC=1.CN(C=O)C>[Br:1][CH2:2][C:3]1[C:4]([C:9]([Cl:14])=[O:11])=[CH:5][CH:6]=[CH:7][CH:8]=1

참가 물질

5

반응물 2

HCID 24386Thionyl ChlorideHCID 3460032-(Bromomethyl)benzoic acid

생성물 1

HCID 122516322-Bromomethylbenzoyl chloride

시약·촉매·용매 2

HCID 6228Dimethylformamide촉매HCID 241Benzene용매

실험 절차

--A solution of α-bromotoluic acid (1.08 g) in dry benzene (10 ml) was stirred for 2 hours with thionyl chloride (0.73 ml) and dry DMF (five drops). The reaction mixture was evaporated to dryness, taken up in toluene and evaporated again. The crude product was crystallized from n-hexane (10 ml, charcoal) thereby obtaining pure α-bromotoluic acid chloride (0.95 g) as white flakes.

후처리

  1. customThe reaction mixture was evaporated to dryness
  2. customevaporated again
  3. customThe crude product was crystallized from n-hexane (10 ml, charcoal)

출처 및 근거

ORD 기록
ord-a9975bce2bb948979e1ab38e7d6a5308
출처 데이터셋
uspto-grants-1989_09
특허 번호
US04863914

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