Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Potassium Hydroxide → 7-chloro-3-ethynyl-4,5-dihydro-5-methyl-6H-imidazo[1,5-a][1,4]benzodiazepin-6-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Potassium Hydroxide | HCID 14797 | — |
| 반응물 | 7-chloro-4,5-dihydro-5-methyl-3-[(trimethylsilyl)ethynyl]-6H-imidazo[1,5-a][1,4]benzodiazepine--one | HCID 70394539 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | 7-chloro-3-ethynyl-4,5-dihydro-5-methyl-6H-imidazo[1,5-a][1,4]benzodiazepin-6-one | HCID 19851533 | — |
반응 단계
12.7 g (37 mmol) of 7-chloro-4,5-dihydro-5-methyl-3-[(trimethylsilyl)ethynyl]-6H-imidazo[1,5-a][1,4]benzodiazepine--one was dissolved in 40 ml of methanol and treated with 40 ml of 1N potassium hydroxide solution. After stirring for 1 hour the methanol was distilled off and the aqueous suspension was cooled and suction filtered. After drying there was obtained 7-chloro-3-ethynyl-4,5-dihydro-5-methyl-6H-imidazo[1,5-a][1,4]benzodiazepin-6-one of melting point 194°-195°.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04863920 |
| 출처 데이터셋 | uspto-grants-1989_09 |
| ORD ID | ord-37488c5ae09245d3ab0f0f9c6342a540 |
| 출처 메모 | uspto-grants-1989_09 |