Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium Iodide → 2-Iodo-4-(trifluoromethyl)phenol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium Iodide | HCID 5238 | — |
| 반응물 | 4-(Trifluoromethyl)phenol | HCID 67874 | — |
| 용매 | Hydrochloric Acid | HCID 313 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 2-Iodo-4-(trifluoromethyl)phenol | HCID 11572816 | 91.5% |
반응 단계
4-(trifluoromethyl)-phenol (8 g) in anhydrous DMF (80 ml) was cooled to 0° C. NaI (9.06 g) and chloroamine-T (16.1 g) was added portionwise and stirred at room temperature overnight. Then diluted with 2M HCl and extracted with ethylacetate. The organic phase was washed with sodium thiosulfate solution, dried (MgSO4) and concentrated in vacuo. The residue was purified by chromatography (silica, eluting with isohexane:ethyl acetate) to give the sub-title compound as a yellow oil (13 g).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07737135B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-1e2552f608414f098ff5e79320e33a6d |
| 출처 메모 | uspto-grants-2010_06 |