Trimethyl orthoacetate → HCID 178495861, 화합물

HRID 1607085노트

반응식

HRID 1607085 반응식
[NH2:1][C:2]1[N:7]=[C:6]([OH:8])[CH:5]=[CH:4][CH:3]=1.[CH3:9][O:10][C:11](OC)(OC)[CH3:12]>>[CH3:9][O:10][C:11](=[N:1][C:2]1[N:7]=[C:6]([OH:8])[CH:5]=[CH:4][CH:3]=1)[CH3:12]

참가 물질

3

반응물 2

HCID 15050Trimethyl orthoacetateHCID 1785076342-Amino-6-hydroxypyridine

생성물 1

HCID 178495861HCID 178495861, 화합물

실험 절차

4.4 g (40 mmol) of 6-amino-2-hydroxypyridine are heated under reflux for 12 hurs in 30 ml of orthoacetic acid trimethyl ester The reaction mixture is then concentrated by evaporation Ether is added to the residue while stirring, the product crystallising out spontaneously. The product is filtered off with suction and dried under a high vacuum. N-(2-hydroxy-6-pyridyl)-acetimidic acid methyl ester having a melting point of 128°-129° is thus obtained.

후처리

  1. concentrationis then concentrated by evaporation Ether
  2. additionis added to the residue
  3. customthe product crystallising out spontaneously
  4. filtrationThe product is filtered off with suction
  5. customdried under a high vacuum

출처 및 근거

ORD 기록
ord-3be86dfd3d214280b3f286795a2c6ffe
출처 데이터셋
uspto-grants-1989_09
특허 번호
US04863938

반응 노트

불러오는 중…