Potassium Carbonate → N'-(6-Oxo-1,6-dihydropyridin-2-yl)-N,N-dipropylformimidamide

HRID 1607087노트

반응식

HRID 1607087 반응식
[OH:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([NH:8][CH:9]=[N:10][CH2:11][CH2:12][CH3:13])[N:3]=1.[CH2:14](I)[CH2:15][CH3:16].C(=O)([O-])[O-].[K+].[K+]>C(O)C>[CH3:13][CH2:12][CH2:11][N:10]([CH:9]=[N:8][C:4]1[NH:3][C:2](=[O:1])[CH:7]=[CH:6][CH:5]=1)[CH2:14][CH2:15][CH3:16]

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 336431-IodopropaneHCID 178457528HCID 178457528, 화합물

생성물 1

HCID 159470N'-(6-Oxo-1,6-dihydropyridin-2-yl)-N,N-dipropylformimidamide

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

1.8 g (10 mmol) of N-(2-pyridon-6-yl)-N'-propylformamidine and N-(2-hydroxy-6-pyridyl)-N'-propylformamidine, 1.9 g (11 mmol) of propyl iodide and 1.5 g (11.mmol) of potassium carbonate are stirred at 80° for 24 hours in 30 ml of absolute ethanol. The reaction mixture is then filtered and concentrated by evaporation The residue is taken up in methylene chloride, washed with water and then dried over Na2SO4 and concentrated by evaporation. The resulting crude product is purified chromatographically. Crystallisation from methylene chloride/ether yields N-(2-pyridon-6-yl)-N',N'-di-n-propylformamidine and N-(2-hydroxy-6-pyridyl)-N',N'-di-n-propylformamidine having a melting point of 102°-104°.

후처리

  1. filtrationThe reaction mixture is then filtered
  2. concentrationconcentrated by evaporation The residue
  3. washwashed with water
  4. dry with materialdried over Na2SO4
  5. concentrationconcentrated by evaporation
  6. customThe resulting crude product is purified chromatographically
  7. customCrystallisation from methylene chloride/ether

출처 및 근거

ORD 기록
ord-1ac1a6175d71461baf3138effbf546c5
출처 데이터셋
uspto-grants-1989_09
특허 번호
US04863938

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