Nitric Acid → 4-[(2-Aminoethyl)amino]-4-oxobutan-2-yl nitrate

HRID 1607125노트

반응식

HRID 1607125 반응식
[OH:1][CH:2]([CH3:10])[CH2:3][C:4]([NH:6][CH2:7][CH2:8][NH2:9])=[O:5].[N+:11]([O-])([OH:13])=[O:12]>C(OCC)C>[O:1]([CH:2]([CH3:10])[CH2:3][C:4]([NH:6][CH2:7][CH2:8][NH2:9])=[O:5])[N+:11]([O-:13])=[O:12]

참가 물질

4

반응물 2

HCID 944Nitric AcidHCID 13715405HCID 13715405, 화합물

생성물 1

HCID 137153344-[(2-Aminoethyl)amino]-4-oxobutan-2-yl nitrate

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

30 g. 2-(3-Hydroxybutanoylamino)-ethylamine are slowly introduced, with stirring at 5° to 10° C., into 100% nitric acid. After stirring for 2 hours at 0° to 5° C., the reaction solution is stirred into 1 liter of ice-cooled anhydrous diethyl ether, the supernatant ethereal layer is decanted off, the separated oil is covered with methylene chloride and the base is liberated with sodium carbonate. After suction filtration and evaporation in a vacuum at a maximum bath temperature of 20° C., there are obtained 33 g. (84% of theory) of base in the form of an oil.

후처리

  1. customthe supernatant ethereal layer is decanted off
  2. filtrationAfter suction filtration and evaporation in a vacuum at a maximum bath temperature of 20° C., there
  3. customare obtained 33 g

출처 및 근거

ORD 기록
ord-164b2e6913224446aa13747c5396098b
출처 데이터셋
uspto-grants-1989_09
특허 번호
US04863949

반응 노트

불러오는 중…