Trifluoroacetic acid → HCID 11552535, 화합물

HRID 16072노트

반응식

HRID 16072 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([C:11]2[CH:16]=[C:15]([Cl:17])[CH:14]=[CH:13][C:12]=2[O:18][CH2:19][C:20]([O:22]C(C)(C)C)=[O:21])[CH:5]=[CH:6][C:7]=1[S:8]([CH3:10])=[O:9].C(O)(C(F)(F)F)=[O:28]>>[Cl:1][C:2]1[CH:3]=[C:4]([C:11]2[CH:16]=[C:15]([Cl:17])[CH:14]=[CH:13][C:12]=2[O:18][CH2:19][C:20]([OH:22])=[O:21])[CH:5]=[CH:6][C:7]=1[S:8]([CH3:10])(=[O:9])=[O:28]

참가 물질

3

반응물 2

HCID 6422Trifluoroacetic acidHCID 866203721,1-Dimethylethyl [[3',5-dichloro-4'-(methylsulfinyl)[1,1'-biphenyl]-2-yl]oxy]acetate

생성물 1

HCID 11552535HCID 11552535, 화합물

실험 절차

A solution of the product from step d) (73 mg) in TFA (3 ml) was stirred for 2 h. The solvent was removed in vacuo, water was added and the mixture was extracted with dichloromethane (three times). The organic extracts were dried (MgSO4), evaporated and triturated with ether to give the title compound (46 mg) as a white solid. M.p. 140-2° C.

후처리

  1. customThe solvent was removed in vacuo, water
  2. additionwas added
  3. extractionthe mixture was extracted with dichloromethane (three times)
  4. dry with materialThe organic extracts were dried (MgSO4)
  5. customevaporated
  6. customtriturated with ether

출처 및 근거

ORD 기록
ord-4d43f8afcb5d4b9f9222be483f1f66a8
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07737135B2

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