1,1-Dimethylethyl [[3',5-dichloro-4'-(methylsulfinyl)[1,1'-biphenyl]-2-yl]oxy]acetate → HCID 67277260, 화합물

HRID 16073노트

반응식

HRID 16073 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([C:11]2[CH:16]=[C:15]([Cl:17])[CH:14]=[CH:13][C:12]=2[O:18][CH2:19][C:20]([O:22]C(C)(C)C)=[O:21])[CH:5]=[CH:6][C:7]=1[S:8]([CH3:10])=[O:9]>C(O)(C(F)(F)F)=O>[Cl:1][C:2]1[CH:3]=[C:4]([C:11]2[CH:16]=[C:15]([Cl:17])[CH:14]=[CH:13][C:12]=2[O:18][CH2:19][C:20]([OH:22])=[O:21])[CH:5]=[CH:6][C:7]=1[S:8]([CH3:10])=[O:9]

참가 물질

3

반응물 1

HCID 866203721,1-Dimethylethyl [[3',5-dichloro-4'-(methylsulfinyl)[1,1'-biphenyl]-2-yl]oxy]acetate

생성물 1

HCID 67277260HCID 67277260, 화합물

시약·촉매·용매 1

HCID 6422Trifluoroacetic acid용매

실험 절차

A solution of the more polar product from Example 2 step d) (35 mg) in TFA (2 ml) was stirred for 24 h. The solvent was removed in vacuo, the mixture was azeotroped with toluene and purified by chromatography (silica, CH2Cl2-MeOH—AcOH as eluent) to give the title compound (22 mg) as a white solid.

후처리

  1. customThe solvent was removed in vacuo
  2. customthe mixture was azeotroped with toluene
  3. custompurified by chromatography (silica, CH2Cl2-MeOH—AcOH as eluent)

출처 및 근거

ORD 기록
ord-8743a24ef4fb40d081cc20c753044d0e
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07737135B2

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