Methyl 2-isocyanatoacetate → 1-(Carbomethoxymethylcarbamoyl)-4-hydroxy-2-pyridone

HRID 1607322노트

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HRID 1607322 반응식
[C:1]([CH2:5][N:6]=[C:7]=[O:8])([O:3][CH3:4])=[O:2].[OH:9][C:10]1[CH:15]=[CH:14][NH:13][C:12](=[O:16])[CH:11]=1>O1CCOCC1>[C:1]([CH2:5][NH:6][C:7]([N:13]1[CH:14]=[CH:15][C:10]([OH:9])=[CH:11][C:12]1=[O:16])=[O:8])([O:3][CH3:4])=[O:2]

참가 물질

4

반응물 2

HCID 2769479Methyl 2-isocyanatoacetateHCID 546960044-Hydroxy-2(1H)-pyridinone

생성물 1

HCID 547236631-(Carbomethoxymethylcarbamoyl)-4-hydroxy-2-pyridone수율 54%

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

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온도
90 °C

실험 절차

A 2.49 g quantity of carbomethoxymethylisocyanate was added to a suspension of 2.00 g of 4-hydroxy-2(1H)-pyridone in 60 ml of dioxane, and the mixture was stirred at 90° C. for 30 minutes. The solvent was distilled off, and ether was added to the residue. The precipitate thus formed was filtered, giving 2.20 g of the title compound in a yield of 54%.

후처리

  1. distillationThe solvent was distilled off
  2. additionether was added to the residue
  3. customThe precipitate thus formed
  4. filtrationwas filtered

출처 및 근거

ORD 기록
ord-a19a7f6eb35a447aba18463ca8449654
출처 데이터셋
uspto-grants-1989_09
특허 번호
US04864021

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