Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Benzyl Bromide → 1-(Benzyloxy)-2-bromo-4-chlorobenzene
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Benzyl Bromide | HCID 7498 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 2-Bromo-4-chlorophenol | HCID 69670 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 1-(Benzyloxy)-2-bromo-4-chlorobenzene | HCID 11551125 | — |
반응 단계
Benzyl bromide (13.1 ml) was added to a stirred mixture of 2-bromo-4-chlorophenol (20.7 g) and potassium carbonate (27.6 g) in DMF (200 ml). After 72 h, the mixture was partitioned between diethylether and water, the organic layer washed with water, dried and the solvent evaporated under reduced pressure. The residue was purified by chromatography (silica, EtOAc/isohexane as eluent). to give the sub-title compound (18.1 g).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07737135B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-271c6ca507864f3b817771dbfa8e87fb |
| 출처 메모 | uspto-grants-2010_06 |