Benzyl Bromide → 1-(Benzyloxy)-2-bromo-4-chlorobenzene

HRID 16075

반응식

HRID 16075 반응식
[CH2:1](Br)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Br:9][C:10]1[CH:15]=[C:14]([Cl:16])[CH:13]=[CH:12][C:11]=1[OH:17].C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C>[Br:9][C:10]1[CH:15]=[C:14]([Cl:16])[CH:13]=[CH:12][C:11]=1[O:17][CH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

5

반응물 3

HCID 7498Benzyl BromideHCID 11430Potassium CarbonateHCID 696702-Bromo-4-chlorophenol

생성물 1

HCID 115511251-(Benzyloxy)-2-bromo-4-chlorobenzene

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

Benzyl bromide (13.1 ml) was added to a stirred mixture of 2-bromo-4-chlorophenol (20.7 g) and potassium carbonate (27.6 g) in DMF (200 ml). After 72 h, the mixture was partitioned between diethylether and water, the organic layer washed with water, dried and the solvent evaporated under reduced pressure. The residue was purified by chromatography (silica, EtOAc/isohexane as eluent). to give the sub-title compound (18.1 g).

후처리

  1. customthe mixture was partitioned between diethylether and water
  2. washthe organic layer washed with water
  3. customdried
  4. customthe solvent evaporated under reduced pressure
  5. customThe residue was purified by chromatography (silica, EtOAc/isohexane as eluent)

출처 및 근거

ORD 기록
ord-271c6ca507864f3b817771dbfa8e87fb
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07737135B2

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