Thionyl Chloride → 2-Methyl-2-(4-pyridinylthio)propanoyl chloride

HRID 1607532노트

반응식

HRID 1607532 반응식
[CH3:1][C:2]([S:7][C:8]1[CH:13]=[CH:12][N:11]=[CH:10][CH:9]=1)([CH3:6])[C:3](O)=[O:4].S(Cl)([Cl:16])=O>>[CH3:1][C:2]([S:7][C:8]1[CH:13]=[CH:12][N:11]=[CH:10][CH:9]=1)([CH3:6])[C:3]([Cl:16])=[O:4]

참가 물질

3

반응물 2

HCID 24386Thionyl ChlorideHCID 135191122-Methyl-2-(4-pyridinylthio)propionic acid

생성물 1

HCID 145999382-Methyl-2-(4-pyridinylthio)propanoyl chloride

실험 절차

9.7 g of the product from step (b) was refluxed for 2 1/2 hours in 225 ml thionyl chloride. The mixture was concentrated in vacuo. The residue was triturated and concentrated in vacuo two times with toluene to yield a white solid which showed the expected carbonyl shift in the IR, indicative of an acid chloride.

후처리

  1. concentrationThe mixture was concentrated in vacuo
  2. customThe residue was triturated
  3. concentrationconcentrated in vacuo two times with toluene
  4. customto yield a white solid which

출처 및 근거

ORD 기록
ord-5985fda140f3428596db54047ef9ad24
출처 데이터셋
uspto-grants-1989_09
특허 번호
US04866068

반응 노트

불러오는 중…