Tetrahydrofuran → Ethoxyprecocene

HRID 1607653노트

반응식

HRID 1607653 반응식
O1CCC[CH2:2]1.[H-].[Al+3].[Li+].[H-].[H-].[H-].[CH3:12][O:13][C:14]1[CH:15]=[C:16]2[C:21](=[CH:22][C:23]=1[O:24][CH3:25])[O:20][C:19]([CH3:27])([CH3:26])[CH2:18][C:17]2=O>>[CH3:12][O:13][C:14]1[CH:15]=[C:16]2[C:21](=[CH:22][C:23]=1[O:24][CH2:25][CH3:2])[O:20][C:19]([CH3:27])([CH3:26])[CH:18]=[CH:17]2

참가 물질

4

반응물 3

HCID 8028TetrahydrofuranHCID 1033734H-1-Benzopyran-4-one, 2,3-dihydro-6,7-dimethoxy-2,2-dimethyl-HCID 21226445Aluminium lithium hydride

생성물 1

HCID 127846Ethoxyprecocene수율 88%

실험 절차

In 80 ml of anhydrous tetrahydrofurane 5.0 g (20 millimoles) of 6-methoxy-7-methoxy-2,2-dimethyl-4-chromanone are dissolved whereupon 1.5 g of lithium aluminum hydride are added in small portions under stirring and the reaction mixture is heated to boiling for an hour. The reaction mixture is worked up according to Example 31. The product is purified by column chromatography. Thus 4.1 g of the desired compound are obtained in the form of a colorless oil, yield 88%.

후처리

  1. additionare added in small portions
  2. temperaturethe reaction mixture is heated
  3. waitto boiling for an hour
  4. customThe product is purified by column chromatography

출처 및 근거

ORD 기록
ord-9a53fcbe4a39471b82e18eec502761f5
출처 데이터셋
uspto-grants-1989_09
특허 번호
US04866089

반응 노트

불러오는 중…