Sodium Carbonate → HCID 14099940, 화합물

HRID 1607934노트

반응식

HRID 1607934 반응식
Cl.Cl[CH:3]([C:17]1[CH:18]=[CH:19][C:20]([CH3:27])=[C:21]([S:23]([NH2:26])(=[O:25])=[O:24])[CH:22]=1)[CH2:4][NH:5][CH2:6][CH2:7][O:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[O:15][CH3:16].C(=O)([O-])[O-].[Na+].[Na+]>C(OCC)(=O)C>[CH3:16][O:15][C:10]1[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=1[O:8][CH2:7][CH2:6][N:5]1[CH2:4][CH:3]1[C:17]1[CH:18]=[CH:19][C:20]([CH3:27])=[C:21]([S:23]([NH2:26])(=[O:25])=[O:24])[CH:22]=1

참가 물질

4

반응물 2

HCID 10340Sodium CarbonateHCID 131062635-{1-Chloro-2-[2-(2-methoxyphenoxy)ethylamino]ethyl}-2-methylbenzenesulfonamide hydrochloride

생성물 1

HCID 14099940HCID 14099940, 화합물수율 88.3%

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

In 50 ml of ethyl acetate was suspended 4.35 g (0.01 mole) of 5-{1-chloro-2-[2-(2-methoxyphenoxy)ethylamino]ethyl}-2-methylbenzenesulfonamide hydrochloride and then 50 ml of an aqueous 10% sodium carbonate solution was added to the suspension with stirring. After further stirringovernight vigorously, the reaction mixture was recovered by decantation. After removing inorganic materials by passing the ethyl acetate layer thusrecovered through a silica gel column (50 ml of silica gel), the reaction product was evaporated to dryness to provide 3.2 g (88%) of colorless resinous 5-{1-[2-(2-methoxyphenoxy)-ethyl]aziridin-2-yl}-2-methylbenzenesulfonamide. The product has the following physicochemical properties.

후처리

  1. customAfter further stirringovernight vigorously, the reaction mixture was recovered by decantation
  2. customAfter removing inorganic materials
  3. customthe reaction product was evaporated to dryness

출처 및 근거

ORD 기록
ord-8e27aff6f8dd4a4bb87501c67ef61e9d
출처 데이터셋
uspto-grants-1989_09
특허 번호
US04868216

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