Water → 2-Methyl-N-(2-methylbutan-2-yl)prop-2-enamide

HRID 1608004노트

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HRID 1608004 반응식
[CH3:1][C:2](=[CH:4][CH3:5])[CH3:3].[C:6](#[N:10])[C:7]([CH3:9])=[CH2:8].S(=O)(=O)(O)[OH:12].O>C(O)(=O)C>[CH3:1][C:2]([NH:10][C:6](=[O:12])[C:7]([CH3:9])=[CH2:8])([CH2:4][CH3:5])[CH3:3]

참가 물질

6

반응물 4

HCID 962WaterHCID 1118Sulfuric AcidHCID 105532-Methyl-2-buteneHCID 31368Methacrylonitrile

생성물 1

HCID 146180182-Methyl-N-(2-methylbutan-2-yl)prop-2-enamide수율 65.2%

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

2-Methyl-2-butene (7.0 g) was added to a stirred mixture of methacrylonitrile (6.7 g) in acetic acid (50 ml) and concentrated sulfuric acid (10 g) at 10° to 20° C. The mixture was allowed to stand overnight at room temperature, and then poured into 200 g of water and extracted with methylene chloride (2×100 ml). The methylene chloride solution was dried over sodium sulfate, the solid filtered off and the methylene chloride evaporated to afford an oily product. Distillation of the product at 10 mm yielded N-(2-methyl-2-butyl)methacrylamide (10.1 g, 65%); bp 84° C.

후처리

  1. extractionextracted with methylene chloride (2×100 ml)
  2. dry with materialThe methylene chloride solution was dried over sodium sulfate
  3. filtrationthe solid filtered off
  4. customthe methylene chloride evaporated
  5. customto afford an oily product
  6. distillationDistillation of the product at 10 mm

출처 및 근거

ORD 기록
ord-a79b999e6d39437c8f1e607cf426637d
출처 데이터셋
uspto-grants-1989_09
특허 번호
US04868310

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