Glycinamide → N-(2-Amino-2-oxoethyl)-2-(4-hydroxy-2-oxopyrrolidin-1-yl)acetamide

반응식

[OH:1][CH:2]1[CH2:6][N:5]([CH2:7][C:8]([O:10]CC)=O)[C:4](=[O:13])[CH2:3]1.[NH2:14][CH2:15][C:16]([NH2:18])=[O:17]>>[OH:1][CH:2]1[CH2:6][N:5]([CH2:7][C:8]([NH:14][CH2:15][C:16]([NH2:18])=[O:17])=[O:10])[C:4](=[O:13])[CH2:3]1

참가 물질

반응물 2

HCID 69020Glycinamide

HCID 12365604Ethyl 2-(4-hydroxy-2-oxopyrrolidin-1-yl)acetate

생성물 1

HCID 11701304N-(2-Amino-2-oxoethyl)-2-(4-hydroxy-2-oxopyrrolidin-1-yl)acetamide수율 43.5%

반응 조건

온도: 80 °C

실험 절차

A mixture of ethyl 4-hydroxy-2-oxo-1-pyrrolidineacetate (0.5 g) and glycinamide (0.6 g) was stirred under nitrogen at 80° C. for 4 hours. After cooling, the mixture was chromatographed on a silica gel column, by eluting with dichloromethane/methanol 7:3, affording the title compound (250 mg).

후처리

temperatureAfter cooling
customthe mixture was chromatographed on a silica gel column
washby eluting with dichloromethane/methanol 7:3

출처 및 근거

ORD 기록: ord-7fc5fbd3df30416bb7ab1159c463d1e1
출처 데이터셋: uspto-grants-1989_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04868313

반응 노트

불러오는 중…