2-Nitro-2-phenyl-1,3-propanediol → 2-Phenyl-1,3-propanediol

HRID 1608044

반응식

HRID 1608044 반응식
[N+]([C:4]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)([CH2:7][OH:8])[CH2:5][OH:6])([O-])=O.[H][H]>[Pd].CO>[C:9]1([CH:4]([CH2:5][OH:6])[CH2:7][OH:8])[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1

참가 물질

5

반응물 2

HCID 2243932-Nitro-2-phenyl-1,3-propanediolHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 2541782-Phenyl-1,3-propanediol

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

12 g. (0.06 mole) of 2-nitro-2-phenyl-1, 3-propanediol, 400 mg. of 5% palladium on calcium carbonate and 150 ml. of methanol are placed in a Parr hydrogenator bottle and reduced with hydrogen overnight. The mixture is filtered through Celite, concentrated to an oil and recrystallized from 30 ml. of toluene. The yield is 7.4 g. (80%) of product, M.P. 52°-4° C.

후처리

  1. filtrationThe mixture is filtered through Celite
  2. concentrationconcentrated to an oil
  3. customrecrystallized from 30 ml

출처 및 근거

ORD 기록
ord-dd8b2b0d25b54515aa678d53f4143dc4
출처 데이터셋
uspto-grants-1989_09
특허 번호
US04868327

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