Water → 2-(4-Benzylmorpholin-2-yl)ethan-1-ol

HRID 1608216노트

반응식

HRID 1608216 반응식
C([O:3][C:4]([CH2:6][CH:7]1[O:12][CH2:11][CH2:10][N:9]([CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH2:8]1)=O)C.[H-].[Al+3].[Li+].[H-].[H-].[H-].C(OCC)(=O)C.O>C(OCC)C>[OH:3][CH2:4][CH2:6][CH:7]1[O:12][CH2:11][CH2:10][N:9]([CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH2:8]1

참가 물질

6

반응물 4

HCID 962WaterHCID 8857Ethyl AcetateHCID 12582571Ethyl (4-benzylmorpholin-2-yl)acetateHCID 21226445Aluminium lithium hydride2회

생성물 1

HCID 146525912-(4-Benzylmorpholin-2-yl)ethan-1-ol수율 99.8%

시약·촉매·용매 1

HCID 3283Diethyl Ether용매2회

반응 조건

온도
25 °C

실험 절차

A solution of 2-ethoxycarbonylmethyl-4-benzylmorpholine (41 g) in diethyl ether (100 ml) is added dropwise to a stirred suspension of lithium aluminum hydride (59.2 g) in diethyl ether (150 ml). The reaction mixture is stirred at 25° C. for 1 hour. The excess of lithium aluminum hydride is decomposed by the successive addition of ethyl acetate and water. The insoluble materials are filtered off, and the filtrate is evaporated to give the title compound (34.4 g) as an oil. The starting material, 2-ethoxycarbonylmethyl-4-benzylmorpholine, is prepared according to the method of F. Loftus [Syn. Commun., 10, 59-73 (1980)].

후처리

  1. filtrationThe insoluble materials are filtered off
  2. customthe filtrate is evaporated

출처 및 근거

ORD 기록
ord-38c5b70e8f36445eab66d2f41d246acf
출처 데이터셋
uspto-grants-1989_09
특허 번호
US04870074

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