4-(2-Chlorobenzyl)-2-chloromethyl-6-methylmorpholine → N-[[4-(2-chlorobenzyl)-6-methyl-2-morpholinyl]methyl]phthalimide

HRID 1608226노트

반응식

HRID 1608226 반응식
[Cl:1][C:2]1[CH:17]=[CH:16][CH:15]=[CH:14][C:3]=1[CH2:4][N:5]1[CH2:10][CH:9]([CH3:11])[O:8][CH:7]([CH2:12]Cl)[CH2:6]1.[K].[C:19]1(=[O:29])[NH:23][C:22](=[O:24])[C:21]2=[CH:25][CH:26]=[CH:27][CH:28]=[C:20]12>CN(C)C=O>[Cl:1][C:2]1[CH:17]=[CH:16][CH:15]=[CH:14][C:3]=1[CH2:4][N:5]1[CH2:10][CH:9]([CH3:11])[O:8][CH:7]([CH2:12][N:23]2[C:22](=[O:24])[C:21]3=[CH:25][CH:26]=[CH:27][CH:28]=[C:20]3[C:19]2=[O:29])[CH2:6]1

참가 물질

4

반응물 2

HCID 198486194-(2-Chlorobenzyl)-2-chloromethyl-6-methylmorpholineHCID 24194345Phthalimide potassium salt

생성물 1

HCID 19848602N-[[4-(2-chlorobenzyl)-6-methyl-2-morpholinyl]methyl]phthalimide수율 94%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
150 °C

실험 절차

A mixture of 4-(2-chlorobenzyl)-2-chloromethyl-6-methylmorpholine (19.7 g), phthalimide potassium salt (14.6 g), and dimethylformamide (150 ml) is stirred at 150° C. for 5 hours. The reaction mixture is poured into ice-water and extracted with diethyl ether. The organic layer is washed successively with water and saturated aqueous sodium chloride solution, and dried over magnesium sulfate. The solvent is distilled off to give the title compound (26 g) as an oil.

후처리

  1. extractionextracted with diethyl ether
  2. washThe organic layer is washed successively with water and saturated aqueous sodium chloride solution
  3. dry with materialdried over magnesium sulfate
  4. distillationThe solvent is distilled off

출처 및 근거

ORD 기록
ord-b4daf0cac8694cad8489942fe69d50af
출처 데이터셋
uspto-grants-1989_09
특허 번호
US04870074

반응 노트

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