Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Potassium Carbonate → Ethyl 7-chloro-6-fluoro-4-hydroxy-8-nitro-3-quinolinecarboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | HCID 178472018 | HCID 178472018 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | Ethyl 7-chloro-6-fluoro-4-hydroxy-8-nitro-3-quinolinecarboxylate | HCID 178469671 | — |
반응 단계
52 g of the product from Example 4 and 18.5 g of K2CO3 are heated at 140° C. for 4 hours in 160 ml of DMF. The mixture is subsequently poured onto ice and acidified, and the precipitated solid is isolated. It is dried and recrystallized from glycol methyl ether acetate. Yield: 35.8 g, melting point: 226°-8° C. (decomposes).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04870182 |
| 출처 데이터셋 | uspto-grants-1989_09 |
| ORD ID | ord-99651179dc094d97bd800861366c4e9b |
| 출처 메모 | uspto-grants-1989_09 |