4-Aminophenol → N-(4-Hydroxyphenyl)nonadecanamide

HRID 1608542노트

반응식

HRID 1608542 반응식
[CH:1]1[C:6]([NH2:7])=[CH:5][CH:4]=[C:3]([OH:8])[CH:2]=1.C(N(CC)CC)C.[C:16](Cl)(=[O:35])[CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH3:34]>C(C(C)=O)C>[OH:8][C:3]1[CH:4]=[CH:5][C:6]([NH:7][C:16](=[O:35])[CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH3:34])=[CH:1][CH:2]=1

참가 물질

5

반응물 3

HCID 4034-AminophenolHCID 8471TriethylamineHCID 4250939Nonadecanoyl chloride

생성물 1

HCID 19597124N-(4-Hydroxyphenyl)nonadecanamide수율 83%

시약·촉매·용매 1

HCID 6569Methyl Ethyl Ketone용매

실험 절차

Under a nitrogen atmosphere, p-aminophenol (109 g) was suspended in methyl ethyl ketone (2000 ml). To this suspension was added triethylamine (253 g) and then was added nonadecanoyl chloride (331 g), followed by refluxing with heating for 2 hours. The reaction mixture was cooled to room temperature to precipitate a white crystal. This crystal was filtered off under reduced pressure and recrystallized from methyl ethyl ketone to obtain 323 g of the desired product. Yield 80%; m.p. 138° C.

후처리

  1. temperatureby refluxing
  2. temperaturewith heating for 2 hours
  3. customto precipitate a white crystal
  4. filtrationThis crystal was filtered off under reduced pressure
  5. customrecrystallized from methyl ethyl ketone

출처 및 근거

ORD 기록
ord-ae9c97feff854c1e9a6833c67b6000ce
출처 데이터셋
uspto-grants-1995_03
특허 번호
US05395815

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