Hydrochloride methanol → 5-[3-(Amino)propylamino]imidazo[1,2-a]pyridine dihydrochloride

HRID 1608590

반응식

HRID 1608590 반응식
C(OC([NH:8][CH2:9][CH2:10][CH2:11][NH:12][C:13]1[N:18]2[CH:19]=[CH:20][N:21]=[C:17]2[CH:16]=[CH:15][CH:14]=1)=O)(C)(C)C.[ClH:22].CO>C(Cl)Cl>[ClH:22].[ClH:22].[NH2:8][CH2:9][CH2:10][CH2:11][NH:12][C:13]1[N:18]2[CH:19]=[CH:20][N:21]=[C:17]2[CH:16]=[CH:15][CH:14]=1

참가 물질

4

반응물 2

HCID 21893726Hydrochloride methanolHCID 23362879Carbamic acid,[3-(imidazo[1,2-a]pyridin-5-ylamino)propyl]-,1,1-dimethylethyl ester

생성물 1

HCID 200866655-[3-(Amino)propylamino]imidazo[1,2-a]pyridine dihydrochloride수율 83%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a suspension of 5-[3-(tert-butoxycarbonylamino)propylamino]imidazo[1,2-a]pyridine (1.742 g, 6 mmoles) in methylene chloride (40 ml) was added hydrogen chloride-methanol (6 ml) and the mixture was stirred at room temperature for 20 hours. After the solvent was distilled off, ethanol (15 ml) and ether (30 ml) were added to the residue. Then, the crystals precipitated were filtered off and washed in turn with ether and a small amount of ethanol to obtain 1.311 g of the desired product (83.0%, pale yellow crystals).

후처리

  1. distillationAfter the solvent was distilled off
  2. additionethanol (15 ml) and ether (30 ml) were added to the residue
  3. customThen, the crystals precipitated
  4. filtrationwere filtered off
  5. washwashed in turn with ether

출처 및 근거

ORD 기록
ord-4047a10adb9b4e57b56f5bb839a4179f
출처 데이터셋
uspto-grants-1995_03
특허 번호
US05395839

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