Potassium Carbonate → 1-[(Benzyloxy)methyl]-2,4,5-tribromoimidazole
반응식
[Br:1][C:2]1[NH:6][C:5]([Br:7])=[N:4][C:3]=1[Br:8].C([O-])([O-])=O.[K+].[K+].Cl[CH2:16][O:17][CH2:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1>CN(C=O)C>[CH2:18]([O:17][CH2:16][N:4]1[C:3]([Br:8])=[C:2]([Br:1])[N:6]=[C:5]1[Br:7])[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1참가 물질
5
실험 절차
Tribromoimidazole (2.0 g, 6.6 mmol) in 25 mL of DMF solution was treated with powdered K2CO3 (12.7 g, 91.6 mmol). To the vigorously stirring suspension was added dropwise benzyl chloromethyl ether (1.4 g, 9.2 mmol). After 18 hours, the reaction mixture was filtered. The filtrate was concentrated in vacuo. The residue was chromatographed as described previously. The product was used immediately in Example 39.
후처리
- filtrationthe reaction mixture was filtered
- concentrationThe filtrate was concentrated in vacuo
- customThe residue was chromatographed
출처 및 근거
- ORD 기록
- ord-54616f6280b143efb404cbf2998a87ea
- 출처 데이터셋
- uspto-grants-1995_03
- 특허 번호
- US05395932
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