Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium Carbonate → 2-Chloro-4-(5-chloro-2-methoxyphenyl)benzoic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium Carbonate | HCID 10340 | — |
| 반응물 | 1,4-Dioxane | HCID 31275 | — |
| 반응물 | 5-Chloro-o-anisic acid | HCID 76970 | — |
| 반응물 | 4-Bromo-2-chlorobenzoic acid | HCID 108829 | — |
| 촉매 | Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+) | HCID 178418228 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | 2-Chloro-4-(5-chloro-2-methoxyphenyl)benzoic acid | HCID 53227577 | 79.2% |
반응 단계
4-bromo-2-chlorobenzoic acid (0.4 g), 5-chloro-2-methoxybenzoic acid (0.4 g), Pd(dppf)Cl2 (0.12 g), sodium carbonate (0.9 g), dioxan (15 ml) and methanol (5 ml) were charged to a flask and heated at reflux for 16 h. Cooled to room temp and filtered (hyflo). The filtrate was concentrated in vacuo, then dissolved in ethyl acetate. The suspension was made basic by addition of dilute NaOH. The aqueous layer was separated and acidified using 2M HCl, extracted with EtOAc, dried (MgSO4) and evaporated in vacuo to give the sub-title compound Yield 0.4 g
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07737135B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-ab2b160fe763407f91689f6ef0679c8c |
| 출처 메모 | uspto-grants-2010_06 |