참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | 2-Mercaptobenzoic Acid | HCID 5443 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 1-Fluoro-2-nitrobenzene | HCID 73895 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 2-[(2-Nitrophenyl)sulfanyl]benzoic acid | HCID 376978 | 77.5% |
반응 단계
In 300 ml of N,N-dimethylformamide were suspended 30.8 g of thiosalicylic acid, 28.2 g of 2-fluoronitrobenzene and 69.0 g of potassium carbonate, and the mixture was stirred at 100° C. for 2 hours. After cooling, water was added and acidified with hydrochloric acid and the crystals separated out therefrom were collected by filtration and washed with water. The crystals were then dissolved in ethyl acetate and the solution was dried over magnesium sulfate and filtered. The filtrate was concentrated and the crystals separated out therefrom were collected by filtration and dried to give 42.6 g of the title compound as yellow prisms, m.p. 169°-171° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US05399703 |
|---|
| 출처 데이터셋 | uspto-grants-1995_03 |
|---|
| ORD ID | ord-b78895024832442eaeaca2880d2021f5 |
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| 출처 메모 | uspto-grants-1995_03 |
|---|
