HCID 15136077, 화합물 → HCID 20084322, 화합물

HRID 1609316노트

반응식

HRID 1609316 반응식
[CH:1]1([C:8]([CH2:10]Br)=O)[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[N+:12]([C:15]1[CH:16]=[C:17](/[CH:21]=[CH:22]/[C:23](=[S:25])[NH2:24])[CH:18]=[CH:19][CH:20]=1)([O-:14])=[O:13]>C(O)C>[CH:1]1([C:8]2[N:24]=[C:23](/[CH:22]=[CH:21]/[C:17]3[CH:18]=[CH:19][CH:20]=[C:15]([N+:12]([O-:14])=[O:13])[CH:16]=3)[S:25][CH:10]=2)[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

참가 물질

4

반응물 2

HCID 15136077HCID 15136077, 화합물HCID 218423502-Bromo-1-cycloheptylethan-1-one

생성물 1

HCID 20084322HCID 20084322, 화합물수율 62.7%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A solution composed of 6.57 g of bromomethyl cycloheptyl ketone, 6.24 g of (E)-3-(3-nitrophenyl)-2-propenethioamide and 100 ml of ethyl alcohol was heated to reflux for 16 hr afterwhich it was diluted with 200 ml of ice water and extracted with methylene chloride. The combined extracts were washed with saturated sodium bicarbonate, brine, dried (MgSO4) and condensed in vacuo to yield 6.17 g of (E)-4-cycloheptyl-2-[2-(3-nitrophenyl)ethenyl]thiazole; m.p. 60° C. after crystallization from ethyl ether/hexane.

후처리

  1. temperaturewas heated
  2. temperatureto reflux for 16 hr afterwhich it
  3. extractionextracted with methylene chloride
  4. washThe combined extracts were washed with saturated sodium bicarbonate, brine
  5. customdried
  6. custom(MgSO4) and condensed in vacuo

출처 및 근거

ORD 기록
ord-440ee59629f549eba729bc9fb4e8f08a
출처 데이터셋
uspto-grants-1995_03
특허 번호
US05399702

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