Ethyl bromopyruvate → Ethyl 2-cyclobutylthiazole-4-carboxylate

HRID 1609330

반응식

HRID 1609330 반응식
[CH:1]1([C:5](=[S:7])[NH2:6])[CH2:4][CH2:3][CH2:2]1.Br[CH2:9][C:10](=O)[C:11]([O:13][CH2:14][CH3:15])=[O:12].C(=O)(O)[O-].[Na+]>C(O)C>[CH2:14]([O:13][C:11]([C:10]1[N:6]=[C:5]([CH:1]2[CH2:4][CH2:3][CH2:2]2)[S:7][CH:9]=1)=[O:12])[CH3:15]

참가 물질

5

반응물 3

HCID 66144Ethyl bromopyruvateHCID 516892Sodium BicarbonateHCID 22141088Cyclobutanecarbothioamide

생성물 1

HCID 54513950Ethyl 2-cyclobutylthiazole-4-carboxylate수율 39.3%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A mixture composed of 9.7 g of cyclobutancarbothioamide, 16.5 g of ethyl bromopyruvate and 200 ml of ethyl alcohol was heated to reflux for 1 hr. The reaction mixture was partially condensed in vacuo and the residual materials were diluted with ice water and and excess of saturated sodium bicarbonate solution. The solids were collected to yield 7.0 g of 2-cyclobutyl-4-thiazolecarboxylic acid ethyl ester; m.p. 48°-50° C. after recrystallization from pentane.

후처리

  1. temperaturewas heated
  2. temperatureto reflux for 1 hr
  3. customcondensed in vacuo
  4. customThe solids were collected

출처 및 근거

ORD 기록
ord-df771a0a379b406ea2b9b346b05952b7
출처 데이터셋
uspto-grants-1995_03
특허 번호
US05399702

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